Cerebrovascular Disorders and Stroke Recovery

Jukka Jolkkonen
PhD, Adjunct Professor
Research Director

University of Eastern Finland
Institute of Clinical Medicine / Neurology
P.O.Box 1627 (Yliopistonranta 1C)
FI-70210 Kuopio
Finland

+358-(0)40-355 2519
jukka.jolkkonen (at) uef.fi

Major Research Interests

  • Mechanisms underlying brain repair following stroke and development of restorative therapies to enhance functional recovery.

Research Methods

  • Experimental stroke models, sensorimotor and cognitive behavioral tests, histology, electron microscopy, stereological counting methods and different imaging modalities (SPECT, MRI).

Academic Degrees

  • MSc (Biochemistry), University of Kuopio, 1983
  • PhD, University of Kuopio (Clinical Biochemistry), 1991
  • Adjunct Professor (Docent) in Neurobiology, University of Kuopio, 1994

Major Positions and Appointments

  • Postdoctoral Fellow, Pharmacology Group, University of London, UK, 1991-93
  • Senior Scientist, Department of Neurology, University of Kuopio, 1994-2005
  • Reasearch Director, University of Eastern Finland, 2005-
  • Visiting Professor, China Medical University, China, 2012- 

Selected Publications

Top three behavioral tests in cell therapy studies after stroke – difficult to stop a moving train. Cui L, Golubczyk D, Jolkkonen J. Stroke 48:3165-3167, 2017

The future of animal modeling for post-stroke tissue repair. Modo MM, Jolkkonen J, Zille M, Boltze J. Stroke, in press

Inhibition of nkcc1 promotes axonal growth and motor recovery in ischemic rats. Mu XP, Wang HB, Cheng X, Yang L, Sun XY, Qu HL, Zhao SS, Zhou ZK, Liu TT, Xiao T, Song B, Jolkkonen J, Zhao CS. Neuroscience 365:83-93, 2017

Cell therapy in stroke - cautious steps towards a clinical treatment. Detante O, Muir K, Jolkkonen J. Transl Stroke Res, in press

Behavioral outcome measures to improve experimental stroke research. Balkaya MG, Trueman R, Boltze J, Corbett D, Jolkkonen J. Behav Brain Res, in press

Chloride co-transporter NKCC1 inhibitor bumetanide enhances neurogenesis and behavioral recovery in rats after experimental stroke. Xu W, Mu X, Wang H, Song C, Ma W, Jolkkonen J, Zhao C. Mol Neurobiol 54:2406-2414, 2017

Editorial. The current state of cell therapies for cerebrovascular diseases. Jolkkonen J, Mendez-Otero R, Rodriguez de Freitas G, Boltze J, Rosado-de-Castro PH. Stem Cells Int 2016, ID 5215824, 2 pages

Increasing the validity of cerebrovascular disease models for translational stem cell research. Boltze J, Nitzsche F, Jolkkonen J, Nitzsche B, Wagner D-C. Stem Cells 35:1141-53, 2017

The MSC adhesion cascade - insights into homing and transendothelial migration. Nitzsche F, Müller C, Lukomska B, Jolkkonen J, Deten A, Boltze J. Stem Cells 35:1446-60, 2017

Induced expression of alpha-4 integrin subunit in human mesenchymal stem cells using a potentially clinically applicable mRNA-based approach. Nowakowski A, Andrzejewska A, Boltze J, Nitzsche F, Cui L, Jolkkonen J, Walczak P, Lukomska B, Janowski M. Sci Reports 7:1103, 2017

Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable (SRRR) translational working group. Corbett D, Carmichael ST, Murphy TH, Jones TA, Schwab ME, Jolkkonen J, Clarkson AN, Dancause N, Wieloch T, Johansen-Berg H, Neilson N, McCullough LD, Joy MT. Int J Stroke 12:462-471, 2017

Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable (SRRR) translational working group. Corbett D, Carmichael ST, Murphy TH, Jones TA, Schwab ME, Jolkkonen J, Clarkson AN, Dancause N, Wieloch T, Johansen-Berg H, Neilson N, McCullough LD, Joy MT. Neurorehabil Neural Repair 31:699-707, 2017

ITGA-4 overexpression on allogeneic mesenchymal stromal cells did not show improved homing but improved safety after intra-carotid injection into a rat ischemic stroke model. Cui L, Nitzsche N, Pryazhnikov E, Tibeykina M, Tolppanen L, Rytkönen J, Huhtala T, Mu J, Khirug L, Boltze J, Jolkkonen J. Stroke 48:2895-2900, 2017

Increased protein expression levels of pCREB, BDNF and SDF-1/CXCR4 in the hippocampus may be associated with enhanced neurogenesis induced by environmental enrichment. Zhang XQ, Mu JW, Wang HB, Jolkkonen J, Liu TT, Xiao T, Zhao M, Zhang CD, Zhao CS. Mol Med Rep 14:2231-7, 2016