Molecular Basis of Aging and Alzheimer's Disease

Antero Salminen 
Research Director, Emeritus

University of Eastern Finland
Institute of Clinical Medicine / Neurology
P.O.Box 1627 (Yliopistonranta 1C)
FI-70211 Kuopio
Finland


+358-(0)50 574 07 40
antero.salminen (at) uef.fi

Major Positions and Appointments

  • Research Associate, Academy of Finland, 1982-85 
  • Junior Research Fellow, Academy of Finland, 1987-1990
  • Senior Research Fellow, Academy of Finland, 1992-1993
  • Professor of Cell Biology, University of Jyväskylä, 1993-95 
  • Research Director, University of Eastern Finland, 1995-2014
  • Research Director Emeritus, University of Eastern Finland, 2014- 
  • Visiting Scientist:
    • University of California, Berkeley, 1986-87 
    • National Cancer Institute, NIH, Bethesda, 1987-89
    • University of Hamburg, Medical School, Hamburg, 1990-92 
    • Baylor College of Medicine, Houston, 1993

Recent Review Articles

AGING PROCESS

Salminen A. Activation of immunosuppressive network in the aging process. Ageing Res. Rev. 2020 doi: 10.1016/j.arr.2019.100998.

Salminen A, Kauppinen A, Kaarniranta K. AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging. J. Mol. Med. (Berl) 97, 1049-1064, 2019.

Salminen A, Kaarniranta K, Kauppinen A. Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency. Cell. Mol. Life Sci. 76, 1901-1918, 2019.

Salminen A, Kaarniranta K, Kauppinen A. The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process. Ageing Res. Rev. 48, 1-10, 2018.

Salminen A, Kauppinen A, Kaarniranta K. Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence. Biogerontology 19, 325-339, 2018.

Salminen A, Kaarniranta K, Kauppinen A. Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): impact on cancer and age-related chronic inflammatory disorders. Int. Immunopharmacol. 61, 231-240, 2018.

Salminen A, Kaarniranta K, Kauppinen A. Integrated stress response stimulates FGF21 expression: systemic enhancer of longevity. Cell. Signal. 40, 10-21, 2017.

Salminen A, Kaarniranta K, Kauppinen A. Regulation of longevity by FGF21: interaction between energy metabolism and stress responses. Ageing Res. Rev. 37, 79–93, 2017.

Salminen A., Kauppinen A., Kaarniranta K. FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process. J. Mol. Med. (Berl) 95, 123-131, 2017.

Salminen A, Kaarniranta K, Kauppinen A. Age-related changes in AMPK activation: role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways. Ageing Res. Rev. 28, 15-26, 2016.

Salminen A, Kaarniranta K, Kauppinen A. Hypoxia-inducible histone lysine demethylases: impact on the aging process and age-related diseases. Aging Dis. 7, 180-200, 2016.

Salminen A, Kauppinen A, Kaarniranta K. AMPK/Snf1 signaling regulates histone acetylation: impact on gene expression and epigenetic functions. Cell. Signal. 28, 887-895, 2016.

Salminen A, Kaarniranta K, Kauppinen A. AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms. Biogerontology 17, 655-680, 2016.  

Salminen A, Kauppinen A, Kaarniranta K. 2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process. Cell. Mol. Life Sci. 72, 3897-3914, 2015.

Salminen A, Kaarniranta K, Hiltunen M, Kauppinen A. Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process. Cell. Signal. 26, 1598-1603, 2014.

Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the aging process. Ageing Res. Rev. 16, 45-65, 2014.

Salminen A, Kaarniranta K, Hiltunen M, Kauppinen A. Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process. J. Mol. Med. (Berl) 92, 1035-1043, 2014.

ALZHEIMER'S DISEASE

Salminen A, Kaarniranta K, Kauppinen A. ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease. J. Mol. Med. (Berl) 98, 633-650, 2020.

Salminen A, Kaarniranta K, Kauppinen A. The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease. Cell. Mol. Life Sci. 75, 3099-3120, 2018.

Salminen A, Kauppinen A, Kaarniranta K. Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease. J. Neurochem. 140, 536-549, 2017.

Salminen A, Jouhten P, Sarajärvi T, Haapasalo A, Hiltunen M. Hypoxia and GABA shunt activation in the pathogenesis of Alzheimer's disease. Neurochem. Int. 92, 13-24, 2016.

Salminen A, Haapasalo A, Kauppinen A, Kaarniranta K, Soininen H, Hiltunen M. Impaired mitochondrial energy metabolism in Alzheimer's disease: impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. Prog. Neurobiol. 131, 1-20, 2015.

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Impaired autophagy and APP processing in Alzheimer's disease: the potential role of Beclin 1 interactome. Prog. Neurobiol. 106-107, 33-54, 2013.

AGE-RELATED MACULAR DEGENERATION (AMD)

Kauppinen A, Kaarniranta K, Salminen A. Potential role of myeloid-derived suppressor cells (MDSCs) in age-related macular degeneration (AMD). Front. Immunol. 11, 384, 2020.

Kaarniranta K, Uusitalo H, Blasiak J, Felszeghy S, Kannan R, Kauppinen A, Salminen A, Sinha D, Ferrington D. Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Prog. Retin. Eye Res. 2020 doi: 10.1016/j.preteyeres.2020.100858.

Kaarniranta K, Koskela A, Felszeghy S, Kivinen N, Salminen A, Kauppinen A. Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration. Biochimie 159, 49-54, 2019.

Hyttinen JM, Blasiak J, Niittykoski M, Kinnunen K, Kauppinen A, Salminen A, Kaarniranta K. DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells: implications for age-related macular degeneration (AMD). Ageing Res. Rev. 36, 64-77, 2017.

Kauppinen A, Paterno JJ, Blasiak J, Salminen A, Kaarniranta K. Inflammation and its role in age-related macular degeneration. Cell. Mol. Life Sci. 73, 1765-1786, 2016.

Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy 9, 973-984, 2013.

Hyttinen JM, Niittykoski M, Salminen A, Kaarniranta K. Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim. Biophys. Acta 1833, 503-510, 2013.