Kuopio Birth Cohort (KuBiCo)

KuBiCo project will generate new knowledge by integrating clinical and analytical data, achieving a stepwise increase in understanding of the combined effects of multiple factors on health and disease. The KuBiCo is aimed to resolve effects of genetics and different stress factors (medicines, nutrition, lifestyle factors and environmental aspects) during pregnancy on health status of the mother and the child. Altogether the final data base will include 10 000 mother-child pairs. All pregnant women who will give a birth at Kuopio University Hospital can participate in the KuBiCo project. The KuBiCo project is a joint research project between University of Eastern Finland (UEF), Kuopio University Hospital (KUH) and National Institute of Health and Welfare (THL). The project has been approved by the Research Ethics Committee of Hospital District of Central Finland.

Pregnant women are recruited on their first visit to maternity clinic. After an electronic consent electronic questionnaires focused on common medications and environmental and psychosocial exposures during pregnancy including alcohol consumption, cigarette smoking, and maternal depression are sent to mothers via email. Basic information about maternal diseases, previous pregnancies, use of medications, tobacco and alcohol during the pregnancy are obtained during the 1st trimester and 3rd trimester of the pregnancy via electronic questionnaire.

Environmental questionnaire is obtained during 1st trimester and includes questions about living environment, animal contacts, exposure to air pollution, tobacco smoking or exposure to passive smoking, frequency of using mobile phone and exposure to noise pollution.

Web-based food frequency (FFQ) are obtained twice during the pregnancy (1st trimester, 3rd trimester). The FFQ comprises a food list of 157 food items with 9 frequency response options ranging from 'Never' to '6 or more times per day'. The output is provided more than 60 nutrients and 100 food groups. FFQ includes specific questions about nutrition and supplement intake and provides a tool for counting the intake of specific nutrients and food groups. . In KuBiCo FFQ has been further developed to produce personal feedback about nutrition at the first and third trimester of pregnancy.

KuBiCo will be extremely valuable when children, partly still unborn, who will enter the study will grow old, and researchers in the future will have a chance to study factors affecting during pregnancy to our health in adulthood. 

More information about KuBiCo: sari.voutilainen at uef.fi or www.kubico.fi