Follow-up study with randomized clinical vitamin D supplementation trial on patients with depression (DepFuD)
Department of Psychiatry, Kuopio University Hospital, in collaboration with UEF Nutritional Epidemiologist Group.
In the light of the global disease burden statistics, the efficacy of current treatments for depression appears insufficient. Thus, research on novel treatment interventions and predictors for good treatment response are warranted. Earlier prospective follow-up studies and intervention studies suggest that several bio-psychosocial factors, including high serum concentrations of vitamin D, are related to better treatment outcomes.
Follow-up study with randomized clinical vitamin D supplementation trial on patients with depression (DepFuD) is a follow-up study with randomized clinical vitamin D supplementation trial on patients with depression, which starter in 2015 in Department of Psychiatry, Kuopio University Hospital. In this setting, the aim is to
1) investigate and characterize factors related to recovery from depression and working ability in depression patients in the long-term. The special interest is in the bio-psychosocial factors.
2) clarify how a six-month intervention with vitamin D supplementation affects treatment response, recovery, and the biological pathways related to depression. This aims to finding potential sub-groups getting benefits from vitamin D supplementation on their mental well-being.
Several measurements are conducted during the intervention and follow-up period. Participants fill a variety of clinical questionnaires and questionnaires with background information. All participants give blood samples for biomarker analyses at time points 3, 6, 18 months and 5 years. Clinical interviews of mental disorders (e.g. SCID-interview) and anthropometric measurements (e.g. weight, height, blood pressure) are also carried out.
The trial starts with a six-month double-blinded randomized controlled trial with vitamin D supplementation. The aim is to recruit altogether 3028 patients with non-psychotic, unipolar depression, aged 18-65 years, who are referred to the recruitment sites for treatment for depression. The participants are randomized to low (10 µg/day) or high (100 µg/day) vitamin D supplementation group. Clinically necessary antidepressant treatments and other treatment continue during the intervention as needed. After six months of intervention, the participants are followed up at 18 months and at 5 years.
DepFuD at clinicaltrials.gov
More information: Anu.ruusunen at kuh.fi