Finnish Vitamin D Trial (FIND)
The FIND is a randomized, double-blind, placebo-controlled, 5-y supplementation study of the benefits and risks of vitamin D in the primary prevention of CVD and cancer among 2600 men ≥60 y and women ≥65 y. The participants will be randomized to 3 groups, with daily supplementation of either: 1) 40 µg/d (1600 IU) of vitamin D3, 2) 80 µg/d (3200 IU) of vitamin D3, or 3) placebo. Compliance, use of non-study drugs or supplements, diet, development of endpoints, and CVD and cancer risk factors will be assessed by questionnaires. Blood samples will be collected for assessment of effect modification by baseline 25-hydroxyvitamin D, as well as for future ancillary studies of genetic/biochemical hypotheses. Event data will be obtained by record linkage from the national computerized hospitalization registry.
The FIND trial is funded by the Academy of Finland, University of Eastern Finland, Juho Vainio Foundation and Finnish Foundation for Cardiovascular Research. FIND in clinicalrials.cov (#NCT01463813).
Researchers involved in the project:
Tomi-Pekka Tuomainen, MD, PhD, Professor of Epidemiology. Co-PI.
Sari Voutilainen, PhD, nutritional epidemiologist, Adjunct Professor. Co-PI.
Jyrki K. Virtanen, PhD, nutritional epidemiologist. Co-PI.
Jaakko Mursu, PhD, nutritional epidemiologist.
Tarja Nurmi, PhD, biochemist.