Genetics of Gene Regulation in Disease

Transcription factors regulate their target genes not only upon specific stimuli, but also through binding to specific DNA sequences. Genetic variation that occurs on those binding sequences may disturb target gene expression. It is also a potential source for the “missing variation” in polygenic diseases that have a clear genetic component in their etiology, such as type 2 diabetes or obesity.

Group Leader

Curriculum Vitae

Sami Heikkinen, PhD, Associate Professor (tenure track)
sami.heikkinen (at)