Current activities of Molecular Pain Research Laboratory

  • Our research is supported by the Finnish Academy (grant ‘Novel mechanisms of migraine’ to Rashid Giniatullin) and CIMO grants to MSc Yevheniia Ishchenko and to MSc Nikita Mikhailov.
  • We developed a method for direct recording of nociceptive activity from nerve terminals in meninges where migraine is originally generated: Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers. doi: 10.3389/fncel.2015.00287
  • We showed pain relief in animal models in vivo and provided a molecular mechanisms for new synthetic agents: Stable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human P2X3 receptors and inflammatory pain. doi: 10.1177/1744806916637704.
  • We study P2X receptor structure and function using a multidisciplinary approach by combining patch clamp technique, imaging, kinetic and molecular models. E-book (R.Giniatullin co-Editor): ATP-gated P2X receptors in health and disease
  • We, in collaboration with the Neuroinflammation Research group, are organizing the International postgraduate course ‘Migraine and Stroke: common and specific mechanisms” to be held on May 6-8, 2016 at the A.I. Virtanen Institute for Molecular Sciences.